Figure 1.

Leptin treatment produces a transcriptional signature distinct from tunicamycin treatment and is defined by the induction genes associated with autophagy and endoplasmic reticulum (ER) stress in mice adipose. (A) Gene Ontology (GO) analysis of the genes set from RNA-seq data (n = 3). (B) Transcription factor family in genome after leptin treatment (n = 3). (C) Transcription factor family in genome after TM treatment (n = 3). (D) Changes in the expression level of genes associated with autophagy and inflammation, which were significantly altered from RNA-seq analysis (n = 3). Values are means ± SEM. *p < 0.05 compared with the vehicle group, ^#p < 0.05 compared with the tunicamycin (TM) group, ^&p < 0.05 compared with the leptin group.