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. 2017 Nov 8;8:1507. doi: 10.3389/fimmu.2017.01507

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Copyright © 2017 Gan, Liu, Luo, Ren, Wu, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autophagy-related gene 5 (Atg5) activates IκB signaling pathway in autophagy-mediated adipocyte inflammation. Adipocytes were infected with pAd-Atg5 and incubated with tunicamycin (TM), followed with or without 3-methyladenine (3-MA) treatment (n = 3). (A) Representative pictures of autophagosome formation monitored by MDC staining. (B) Gene expression of Tnfα, IL-18, and IL-1β. (C) Protein level of phosphorylation IκB, NLRP3, IL-1β, and IL-18. (D) IκB and GAPDH protein levels in cytoplasm and P65 and PCNA protein levels in nuclear extracts of the adipocytes. Full scans of uncropped blots are included in Figure S3. Values are means ± SEM. *p < 0.05 compared with the TM group, ^#p < 0.05 compared with the 3-MA treatment group.