Table 2.
Published cases from 1977 until 2016 of spontaneous tumor lysis syndromes in solid tumors
| Case author | Age/sex | Initial TLS symptom | Cancer type | Sites involved | Treatment | Initial outcome |
|---|---|---|---|---|---|---|
| Gbaguidi et al. 13 | 88/F | Vomiting | Renal Ca. | Large renal + bone + liver | Unknown | Died |
| Okamoto et al. 14 | 62/F | Abd distention | Uterine adeno Ca. | >20 cm pelvic mass + ascites | Chemo, surgery | Survived |
| Saleh et al. 15 | 56/F | Fatigue | Pancreatic adeno Ca. | Large pancreatic mass + liver | All, Rasb, K Binders | Died |
| Wang et al. 16 | 71/F | Skin nodules | GI or ovarian adeno Ca. | Skin + renal + adrenal + lung + liver | All, K Binders, Alk | Died |
| Frestad et al. 1 | 27/M | Abd Pain | Colon mucinous adeno Ca. | Liver + lung + pleura + LAD | Rasb, fibrinogen | Died |
| Norberg et al. 17 | 56/M | Back Pain | Renal Ca. | 10 cm Renal mass + liver + bone + lung | Fluids, all, HD | Died |
| Zakharia et al. 18 | 49/F | Abd Pain | Spindle cell sarcoma | 9 cm RP mass + liver + lung | Fluids, Rasb, HD | Died |
| Goyal et al. 19 | 51/M | Weakness | Gastric adeno Ca. | Liver + bone + adrenal + LAD | Fluids, All, HD | Survived |
| Ali et al. 20 | 66/M | Abd Pain | Cholangiocarcinoma | Extensive liver involvement | Fluids, All | Died |
| Mehrzad et al. 21 | 70/M | Unresponsive | Hepatocellular Ca. | 14 cm liver mass + LAD | Fluids, Alk | Died |
| Mouallem et al. 22 | 69/M | Rectal Bleed | Melanoma | Extensive liver involvement | Fluids | Died |
| Saini et al. 23 | 59/F | Vomiting | CUP: adeno Ca. | Large RP mass + liver + LAD | Fluids, Rasb, HD | Died |
| Kekre et al. 24 | 76/M | Vomiting | Hepatocellular Ca. | 19 cm liver mass | Fluids, All, HD | Died |
| Goyal et al. 25 | 51/F | Anuria | Ductal breast Ca. | 4 cm ulcerated breast mass | Fluids, All | Died |
| Murray et al. 26 | 13/F | Abd distention | GCT | 20 cm pelvic mass + peritoneum | Rasb, Chemo | Survived |
| D'Alessandro et al. 27 | 22/M | Abd distention | GCT: choriocarcinoma | 14 cm RP mass + lung + liver | Rasb, K Binders | Died |
| Abboud et al. 28 | 53/M | Abd Pain | Sq. cell Ca./maxillary sinus | Extensive liver involvement | All, Alk, Rasb | Died |
| Shenoy. 29 | 74/M | Anuria | Squamous cell Ca‐ lung | Bulky necrotic lung mass | All, HD, Chemo | Survived |
| Lin et al. 30 | 72/M | Anorexia | Prostate Ca. | Extensive liver + bone involvement | All, Furosemide, HD | Died |
| Vaisban et al. 31 | 82/F | Weakness | Colon Ca. | Extensive liver involvement | All, Alk | Survived |
| Vaisban et al. 31 | 80/M | Abd Pain | Pheochromocytoma | 20 cm Adrenal mass | All, Alk | Survived |
| Vaisban et al. 31 | 72/M | Weakness | Hepatocellular Ca. | Large liver lesion | All, Alk | Died |
| Pentheroudakis et al. 32 | 52/M | Abd pain | GCT: endodermal sinus | RP LAD + liver + lung | HD, Chemo | Survived |
| Pentheroudakis et al. 32 | 24/M | Abd pain | GCT: Seminoma | 25 cm RP mass + liver | HD, Chemo | Survived |
| Woo et al. 33 | 36/M | Abd distention | Gastric adeno Ca. | 7 cm gastric mass + liver + LADs | Alk, All, HD, Chemo | Died |
| Feld et al. 34 | 72/M | Abd distention | Lung adeno Ca. | Large lung mass + liver | Cal, K Binders, All | Died |
| Sklarin et al. 35 | 62/F | Bone pain | Inflammatory breast Ca. | Breast + liver + lung + bone marrow | All, Chemo | Survived |
| Crittenden et al. 2 | 50/M | Abd distention | CUP: adeno Ca. | Extensive liver + bone + LAD | All, Alk | Died |
Abd, abdominal; All, allopurinol; Alk, alkalinization; Ca, carcinoma; Cal, calcium supplementation; Chemo, chemotherapy; CUP, carcinoma of unknown primary; F, female; HD, hemodialysis; GCT, germ cell tumor; K Binders, potassium Binders; M, male; Mets, metastases; Rasb, rasburicase; RP, retroperitoneal; Sq Cell Ca, squamous cell carcinoma.