Fig. 1.

A) Illustration showing the location of the fiber protein on the adenovirus capsid, as well as the three structural domains of the fiber. B) Schematic adenovirus viral cycle. The adenovirus recognizes its specific receptor (1) triggering its internalization inside the cell (2). Then the virus migrates through the microtubules (3) and introduces the viral genome inside the nucleus (4). The E1A gene is expressed immediately (5) the E1A protein binds pRB releasing the transcription factor E2F and thus the cell cycle arrest (6), which in turn will promote the expression of viral proteins and the genome replication, obtaining the viral progeny (7).