Fig. 2.

Schematic diagram representing the progression of the oncolytic adenovirus cycle following the infection of a tumor cell versus a healthy cell. Although the virus is able to infect normal healthy cells its replication is impaired, thus the cell remains undamaged. On the contrary, the virus replicates in a tumor cell and generates new viral particles, which in turn leads to the lysis of the cell and the spread of these particles to nearby cells.