Table 1.
Classification of MMPs | Type of MMPs | Substrate | Specific role of MMP in liver diseases |
---|---|---|---|
Collagenases | MMP1 | Col I, II, III, VII, VIII, X, gelatin | Over expression in the liver effectively attenuates fibrosis and causes hepatocyte proliferation.23 |
MMP8 | Col I, II, III, VII, VIII, X, aggrecan, gelatin | Promoted leukocyte infiltration in TNF-induced acute hepatitis.24 | |
MMP13 | Col I, II, III, IV, IX, X, XIV, gelatin | Acute liver injury and accelerates liver fibrosis.26 | |
Gelatinases | MMP2 | Gelatin, Col I, II, III, IV, VII, X | Expressed during Liver ischemia/reperfusion (IR) injury.27 |
MMP9 | Gelatin, Col IV, V | Expressed in leukocytes during Ischemia/Reperfusion Injury.30, 31 | |
Stromelysins | MMP3 | Col II, IV, IX, X, XI, gelatin | Expressed in hepatocellular carcinoma.25 |
MMP10 | Col IV, laminin, fibronectin, elastin | Expressed in hepatocellular carcinoma.25 | |
MMP11 | Col IV, fibronectin, laminin, aggrecan | Expressed in normothermic ischemia injury.29 | |
MMP19 | # | Promoted TGF-p signaling in development of liver fibrosis.31 | |
Matrilysins | MMP7 | Fibronectin, laminin, Col IV, gelatin | Expressed in biliary atresia fibrosis.49, 50, 51 |
MMP26 | # | # | |
Membrane Type-MMPs | MMP14 | Gelatin, fibronectin | Expressed in highly invasive hepatocellular carcinoma and expressed in liver fibrosis.33 |
MMP15 | Gelatin, fibronectin | Expression is significantly downregulated post partial hepatectomy. | |
MMP16 | Gelatin, fibronectin, laminin | Expressed in hepatitis, cirrhosis and hepatocellular carcinoma.32 | |
MMP17 | Fibrinogen, fibrin | # | |
MMP24 | # | Expressed post partial hepatectomy.33 | |
MMP25 | # | # | |
Others | MMP12 | Elastin, fibronectin, Col IV | # |
MMP20 | # | # | |
MMP22 | # | # | |
MMP23 | # | # | |
MMP28 | # | # |
#: not reported.