(A) The relationship between myocardial T2* (ms) and T2*-MRI derived hepatic iron concentration (HIC) in adults and children. (B) The relationship between MRI-derived left ventricular ejection fraction (LV EF) and myocardial T2*. The dotted lines represent the limits of normal values for HIC (+7 mg/g dry weight), myocardial T2* (≥20 ms), and LV EF (>56%). ●: Thalassemia major (age, 6–48 years); ○: sickle cell disease (age, 9–19 years); ■: thalassemia intermedia (age, 23–82 years); □: other (age, 3–27 years).