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. 2017 Nov 1;13(11):1450–1457. doi: 10.7150/ijbs.21230

Figure 2.

Figure 2

Correlation analysis between collagen type I expression and clinicopathologic features of colorectal cancer. (A) Collagen type I immunohistochemical staining of colorectal cancer tissues in different stages. Bar = 200 µm. (B) Collagen type I immunohistochemical staining of colorectal cancer tissues in different stages. Bar = 50 µm. (C) Collagen type I expression across individual AJCC-7th stages (I-IV). Collagen type I expression was stronger in stage III/IV CRC tissues than in stage I/II tissues. (D) Collagen type I expression across individual WHO grades (1-3). There was no difference in Collagen type I expression between grade 1 and grade 2. Collagen type I expression was significantly increased in grade 3 colorectal cancer tissues compared with grade 2. (E) Collagen type I expression in CRC with lymph node metastasis (N1) was stronger compared to that in the tissues with no lymph node metastasis (N0). (F) Collagen type I expression in CRC with lymph node metastasis (M1) was stronger compared to that in the tissues with no lymph node metastasis (M0). (G) Collagen type I expression in the stage T3/T4 CRC group was significantly increased compared to that in the stage T2 group. *, p<0.05; **, p<0.01; ***, p<0.001.