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. 2017 Dec 4;17:117. doi: 10.1186/s12935-017-0491-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The mRNA and protein levels of Gli1 and MGMT in U251 cells were significantly inhibited 48 h after treated by 5 μM cyclopamine (a and b). The MGMT promoter statement remained unchanged like the A172 treatment (c). When exposed to TMZ, cell viability treated with cyclopamine was significantly lower than that in the control 72 h after the treatment (d). The percentage of apoptotic cells in U251 cells treated with cyclopamine was significantly higher than in the control at 120 h post-treatment (e)