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. 2017 Dec 4;18:202. doi: 10.1186/s12931-017-0681-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Placebo-adjusted change from baseline in FEV₁ AUC_0-12 on Day 7 (a: GOLDEN 2; b: GOLDEN 6; c: pooled population). AUC, area under the curve. BID, twice daily. CI, confidence interval. FEV₁, forced expiratory volume in 1 second. LS, least squares