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Epileptogenesis via raised reversal potential to GABAergic current. GABAergic interneurons (Int) apply excitatory synaptic input to the principal neurons (Pr) via raised GABA reversal potential in the principal neurons, which in turn increase the whole network activity and induce seizure. (+) excitatory; (−) inhibitory. Downward deflection trace: inhibitory postsynaptic potential (IPSP). Vertical line: action potential
