Figure 5.
Ameliorating effects of p53 activator doxorubicin on cholic acid (CA)‐induced cholestasis in Trp53‐WT mice. Mice were fed with standard or cholic acid supplemented chow for 4 days. Doxorubicin (10 mg·kg−1) or saline was administered once per 3 days. Mice were killed at 24 h after the final doxorubicin treatment, and samples were collected. (A) Morphology of representative livers. Gall bladders are indicated by black arrows. (B) Representative H&E stained liver sections (10 × 10). Apparent subcapsular necrotic foci in the liver are indicated by black arrows. (C–G) Gall bladder volume, levels of serum total bile acid and total bilirubin, as well as serum ALP, ALT and AST activities. Data are the mean ± SEM (n = 5–6). *P < 0.05; NS, not significant.