Figure 4.

Effect of Mg on PLY brain oedema model in infant rats. The amount of Evans Blue (expressed as mm² after filter paper absorption) displaced out of the intracranial space (as a marker of elevated intracranial pressure) at 6 h after treatment with PLY (see Methods) in rats with or without treatment with MgCl₂ (500 mg·kg⁻¹ i.p) at the beginning of the experiment, reveals ameliorated intracranial pressure increase after treatment with Mg²⁺. The intracranial pressure of the PLY‐treated animals is significantly higher than that in the mock and PLY + Mg groups. Data shown are individual values with mean indicated by the horizontal line. *P<0.05, significantly different as indicated.