Table 1.
The main characteristics of all included studies for MTHFR A1298C polymorphism
| Study | Year | Country | CASE | CONTROL | HWE | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA | AC | CC | AA | AC | CC | |||||
| Storti | 2003 | Italy (Europe) | 45 | 47 | 11 | 101 | 86 | 13 | 0.347 | VSD, TOF, DORV, PA, TGA, AC |
| Galdieri | 2007 | Brasil (America) | 35 | 21 | 1 | 19 | 16 | 3 | 0.885 | CHD |
| van Driel | 2008 | Netherland (Europe) | 112 | 90 | 27 | 97 | 129 | 25 | 0.057 | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS |
| Locke | 2010 | USA (America) | 42 | 39 | 6 | 30 | 49 | 9 | 0.090 | ASD, VSD, AVSD |
| Obermann-Borst | 2010 | Netherland (Europe) | 69 | 57 | 13 | 75 | 90 | 18 | 0.227 | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS |
| Xu | 2010 | China (Asia) | 316 | 168 | 18 | 326 | 185 | 16 | 0.091 | Cyanotic Cardiac Disease, ASD, VSD, PDA, Left-sided Obstruction Defects |
| Božovic | 2011 | Europe | 30 | 22 | 2 | 25 | 30 | 3 | 0.113 | ASD, VSD, AVSD, PFO, TOF, PDA, Persistent truncus arteriosus |
| Christensen | 2013 | Canada (America) | 78 | 67 | 12 | 38 | 26 | 5 | 0.849 | VSD, TOF, AS, TGA, AVSD, DORV, PS, CoA, Truncus Arteriosus |
| Sahiner | 2013 | Turkey (Europe) | 45 | 68 | 24 | 31 | 54 | 8 | 0.022 | Obstruction in LV Output, Left-to-right Shunt, Conotruncal Anomalies,Complex Anomalies |
| Wang | 2013 | China (Asia) | 115 | 40 | 5 | 133 | 47 | 8 | 0.155 | CHD |
| Zidan | 2013 | Egypt (Africa) | 16 | 27 | 37 | 30 | 26 | 24 | 0.002 | ASD, VSD, PDA, Combined lesion, PS, TOF, HLHS |
| Chao | 2014 | China (Asia) | 13 | 2 | 2 | 15 | 19 | 0 | 0.024 | PDA |
| Huang | 2014 | China (Asia) | 111 | 56 | 3 | 146 | 54 | 6 | 0.712 | TOF |
| Sayin Kocakap | 2014 | Turkey (Europe) | 20 | 36 | 13 | 51 | 37 | 11 | 0.288 | PS, ASD, VSD, AVSD, TAPVR, TA, PA |
| Li | 2015 | China Asia) | 114 | 36 | 0 | 131 | 19 | 0 | 0.408 | VSD, ASD, PDA, TOF, CoA, AS, PS, TGA, DORV, Persistent truncus arteriosus |
| Koshy | 2015 | India (Asia) | 27 | 32 | 37 | 58 | 20 | 22 | 0 | TOF, DORV, PA-VS, TA, IAA |
AC Aortic Coarctation, AS Aortic Stenosis, ASD Atrial septal defect, AVSD Atrioventricular septal defect, CHD congenital heart disease, CoA Coarctation of the aorta, DORV Double outlet right ventricle, HLHS Hypoplastic left heart syndrome, IAA Interrupted aortic arch, PA Pulmonary atresia, PDA Patent ductus arteriosus, PS Pulmonary stenosis, TA Tricuspid atresia, TAPVR Total anomalous pulmonary venous return, TGA Transposition of great arteries, TOF Tetralogy of Fallot, VSD Ventricular septal defect