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. 2017 Dec 4;43:108. doi: 10.1186/s13052-017-0425-1

Table 4.

Heterogeneity analysis of the association between MTHFR A1298C polymorphism and CHD

Subgroup analysis	Genetic model
	C vs. A			CC vs. AA			CC vs. AC			AC vs. AA			Dominant model			Recessive model
	Heterogeneity		Meta-regression	Heterogeneity		Meta-regression	Heterogeneity		Meta-regression	Heterogeneity		Meta-regression	Heterogeneity		Meta-regression	Heterogeneity		Meta-regression
	I² (%)	P	P	I² (%)	P	P	I² (%)	P	P	I² (%)	P	P	I² (%)	P	P	I² (%)	P	P
Summary	73.0	0.000		51.1	0.012		0.0	0.569		70.6	0.000		74.5	0.000		14.7	0.289
HWE			0.076			0.002			0.248			0.558			0.308			0.014
Consistent	58.4	0.006		20.3	0.251		0.0	0.859		63.7	0.001		65.3	0.001		0.0	0.709
Inconsistent	75.5	0.007		0.0	0.784		46.0	0.135		83.1	0.000		83.6	0.000		0.0	0.769
Down’s syndrome			0.111			0.106			0.433			0.186			0.143			0.149
Without	73.2	0.000		49.8	0.021		0.0	0.461		71.7	0.000		75.1	0.000		13.6	0.308
With	0.0	0.908		0.0	0.890		0.0	0.941		0.0	0.886		0.0	0.856		0.0	0.940
Region			0.218			0.466			0.492			0.224			0.230			0.534
Europe	68.0	0.008		38.9	0.147		0.0	0.846		68.5	0.007		72.0	0.003		0.0	0.594
Asia	79.2	0.000		60.3	0.039		36.2	0.180		78.9	0.000		80.9	0.000		40.5	0.151
America	44.7	0.164		20.4	0.285		0.0	0.612		40.5	0.186		50.2	0.134		0.0	0.441
Sample size			0.723			0.180			0.679			0.874			0.818			0.214
Large (>100)	38.7	0.110		0.0	0.619		0.0	0.603		57.3	0.016		53.1	0.029		0.0	0.664
Small (<100)	83.8	0.000		64.0	0.011		12.0	0.338		80.7	0.000		84.5	0.000		37.1	0.145