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. 2016 Sep 12;3(3):28. doi: 10.3390/jcdd3030028

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Migration route of the NCCs. (A) NCCs (blue) migrate through and ventral to the sclerotome, guided by repulsive neurotrophin SEMA3A from the dermomyotome; (B) Inset of A. NCCs are guided by repulsive proteins SEMA3A and EphrinB1 over the rostral side of the sclerotome; (C) Within the sclerotome, some NCCs will form dorsal root ganglia (DRG), while others will travel to the aorta. There they will form sympathetic chain ganglia, stimulated by BMPs expressed by the aorta; (D) The cardiac NCCs from the cardiac neural crest will follow the vessels into the heart. Cells in the outflow tract will also secrete BMPs to induce differentiation of the NCCs.