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. 2017 Aug 8;4(3):11. doi: 10.3390/jcdd4030011

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LMNA-associated nuclear inclusions in pediatric DCM. (A) Family pedigrees; (B) LMNA protein structure and conservation of E290 and surrounding residues; Electron microscopy of cardiac tissue in (C) pediatric normal control; (D) pediatric DCM control; and (E,F) patients harboring the LMNA-E290K mutation. Scale bars, 2 μm. Cardiomyocytes in patients with LMNA mutations displayed multiple nuclear blebs and inclusions, highlighted in magnified views (G,H). Scale bars 400 nm and 200 nm, respectively.