Table 2.

Relevant large animal models for cardiac disease (only one reference is listed for each model. See the main text for more references).

Animals	Induced Model	Spontaneous Model
Dogs	MI [10]	ARVC [18]
	Non-ischemic HF [21]	DCM [8] DMD [22]
	SCD [17]	Valvular disease [23]
Sheep	MI [27]	n/a
	SCD [16]
Pigs	Cryoinjury [47]	n/a
	MI [32]
	TOF [40]
Non-human Primates	MI [6] CHF [46]	n/a

ARVC: arrhythmogenic right ventricular cardiomyopathy; DCM: dilated cardiomyopathy; DMD: Duchenne muscular dystrophy; HF: heart failure; MI: myocardial infarction; SCD: sudden cardiac death; TOF: Tetralogy of Fallot.