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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: J Mol Cell Cardiol. 2017 Mar 3;105:59–69. doi: 10.1016/j.yjmcc.2017.03.001

Fig. 9.

Fig. 9

Model illustrating the intracellular signaling pathway leading to cell proliferation and survival in response to NRG-1β treatment. NRG-1β induces phosphorylation of the kinase-dead ErbB3 receptor, which leads to recruitment and phosphorylation of the kinase active ErbB2 receptor. This leads to activation of phosphoinositide-3 kinase (PI3K) with subsequent phosphorylation of protein kinase B (AKT) at serine (S)473 and threonine (T)308. AKT phosphorylates and inactivates GSK-3β, which participates in multiple signaling pathways, per the literature (paper icon).