Table 2.
Enriched functions of human fibroblasts treated with NRG-1β.
| Ontology/pathway | p value | Up-regulated | Down-regulated |
|---|---|---|---|
| Protein localization | 0.001342 | BID, STRADA, AP3S1, MTX2, PEX5, SRGN, SRP19, SRP54, STAM, SYTL3, SYTL4, SDCBP, STX10, TLK1 | RAP3IP, RPAIN, SH3GLB1, SNAPIN, AURKB, CLTA, GOSR1, SNX1, SNX2, VTI1A, ZFYVE16 |
| Ras protein signal transduction | 0.00176 | RASGRP3, ARHGEF3, RHOA, SDCBP | RASSF1, GNB1, APOE, RGL2, RREB1 |
| Apoptosis (ontology) | 0.009091 | ATG5, BID, DFFB, FAS, FAIM, NLRP12, RASSF5, ARHGEF3, CARD8, DEDD2, RTN3, RNF130, SRGN, TRIM69, ZNF346 | ADAMTSL4, BCL2L13, MADD, MCF2L, SH3GLB1, BLCAP, CIB1, CASP2, CADM1, EIF2AK2, ITGB2, IL24, PIGT, PUF60, ZDHHC16 |
| Cell death | 0.019755 | L1CAM, RASSF5, ATXN10 + 15 genes above | 15 genes listed above |
| Pathways in cancer | 0.007181 | BID, FAS, MAX, RASSF5, SMAD2, PTCH1, RHOA, TPM3, VHL, WNT2B | RASSF1, EGF, IKBKG, MSH6, PAX8, PIK3R3, RARB |
| ErbB signaling pathway | 0.019615 | PAK6, RPS6KB1, ABL2 | CAMK2G, EGF, NRG2, PIK3R3 |
| Apoptosis (pathway) | 0.056577 | BID, DFFB, FAS, IRAK4 | IKBKG, PIK3R3, PRKACB |