Fig. 6.

Human AnkB mutations cause cell-autonomous increases in lipid accumulation in differentiated adipocytes. (A) AnkB structure showing the sites of disease-associated variants. Putative pathogenic AnkB variants within the C-terminal domain are shown in red. (B) Variant frequency in Americans of European (EA) and African (AA) descent. Predicted functional effect of these variants on adipocytes is indicated. (C) Lipid droplet size. Data represent mean ± SEM (n = 100 cells for one of three independent experiments).