Fig. 3.

Mutational pathways to increased CTX resistance. (A) Folded β-lactamase enzyme with positions of shared and unique mutations. (B) MIC (lines) and mutational pathways (colored rectangles) for the LL (Left, blue) and SL lines (Right, red). Also mutations in the signal peptide are shown (in gray), including identity of shared mutations; see Fig. S2 for identity of all mutations.