Fig. 2.

Overlap of TCRB templates between tissues and patients. The overlap fraction between two samples is defined as the fraction of templates in tissue j (columns) with sequences that are also detected in tissue i (rows), with the median value reported for within (A) and between (B) patient tissue combinations. (C) On average (thick gray line) and individually (thin gray lines), sequences with high abundance in the tumor are more likely to be detected in normal breast. Similar trends hold for other tissue combinations (SI Appendix, Fig. S4). (D) Overlap between samples observed for each patient is strongly correlated (linear regression with 95% confidence interval and Pearson correlation coefficient, r) with the clonality of the patient’s repertoire. Avg., Average; B, blood; N, normal breast; T, tumor.