Skip to main content
. 2015 May 9;14(4):159–169. doi: 10.1007/s12522-015-0209-5

Table 1.

Effects of each therapy against oocyte aging

Model Mechanism Effects Refs.
Vitamin C, E Mouse Antioxidant action Increase in ovulated oocyte
Improvement of oocyte quality [57]
Melatonin Human a Antioxidant action Improvement of fertilization rate in ART cycle
Improvement of pregnancy rate in ART cycle [60]
Resveratrol Mouse SIRT1 activation Increase in follicular oocyte pool
Improvement in chromosomal alignment on metaphase plates
Decrease in meiotic spindle abnormalities [73]
Calorie restriction Mouse Modification of insulin/IGF‐1, mTOR, and SIRT1 pathways Increase in ovulated oocyte numbers
Decrease in chromosomal aberrations
Decrease in abnormal mitochondrial aggregation [80]
Mitochondrial transfer b Human Supplementation of mitochondrial function Improvement of fertilization rate in ART cycle
Improvement of pregnancy rate in ART cycle [91]

aAmong the patients who failed to become pregnant with a low fertilization rate (≤50 %) in the previous ART cycle

bAUGMENT (Autologous Germline Mitochondrial Energy Transfer)‐IVF has been proposed, but the effect of this therapy has not been validated as yet