Table 1.

MIC value range with geometric mean, mode, and MIC₅₀ and MIC₉₀ values for the different dermatophytic species by the CLSI M38-A2 and EUCAST methodologies.

Antifungals, Dermatophyte Species, and the Methodologies Followed	MIC Distribution (μg/mL) (No. of Isolates)
	0.03	0.06	0.125	0.25	0.5	1	2	4	8	16	+GM	MIC50	MIC90
Itraconazole
T. interdigitale (n = 37)
CLSI	21	13	3	0	0	0	0	0	0	0	0.042	0.03	0.06
EUCAST	7	6	11	0	3	0	0	0	0	0	0.077	0.06	0.125
T. tonsurans (n = 17)
CLSI	15	1	1	0	0	0	0	0	0	0	0.033	0.03	0.06
EUCAST	0	15	1	1	0	0	0	0	0	0	0.07	0.06	0.125
T. rubrum (n = 5)
CLSI	3	2	0	0	0	0	0	0	0	0	0.039	0.03	0.06
EUCAST	1	2	2	0	0	0	0	0	0	0	0.07	0.06	0.125
T. violaceum (n = 3)
CLSI	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
EUCAST	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
M. gypseum (n = 3)
CLSI	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
EUCAST	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
T. verrucosum (n = 1)
CLSI	1	0	0	0	0	0	0	0	0	0	*NA	*NA	*NA
EUCAST	1	0	0	0	0	0	0	0	0	0	*NA	*NA	*NA
Terbinafine
T. interdigitale (n = 37)
CLSI	3	2	5	5	14	5	0	0	2	1	0.375	0.5	1
EUCAST	0	5	0	4	6	15	4	0	2	1	0.683	1	2
T. tonsurans (n = 17)
CLSI	3	0	0	2	2	1	4	2	2	1	0.878	2	8
EUCAST	0	2	1	0	2	2	4	2	3	1	1.379	2	8
T. rubrum (n = 5)
CLSI	1	0	0	0	2	0	0	0	2	0	0.863	0.5	8
EUCAST	0	1	0	0	2	0	0	0	2	0	0.991	0.5	8
T. violaceum (n = 3)
CLSI	2	0	1	0	0	0	0	0	0	0	0.048	0.03	0.125
EUCAST	0	2	1	0	0	0	0	0	0	0	0.076	0.06	0.125
M. gypseum (n = 3)
CLSI	2	0	1	0	0	0	0	0	0	0	0.048	0.03	0.125
EUCAST	0	2	1	0	0	0	0	0	0	0	0.076	0.06	0.125
T. verrucosum (n = 1)
CLSI	0	0	0	0	0	0	0	0	1	0	*NA	*NA	*NA
EUCAST	0	0	0	0	0	0	0	0	0	1	*NA	*NA	*NA
Griseofulvin
T. interdigitale (n = 37)
CLSI	3	2	5	5	14	5	0	0	2	1	0.375	0.5	1
EUCAST	0	5	0	5	11	13	0	0	0	3	0.577	0.5	1
T. tonsurans (n = 17)
CLSI	1	2	0	0	4	3	5	1	0	1	0.777	1	4
EUCAST	0	1	1	1	0	2	4	3	4	1	1.995	2	8
T. rubrum (n = 5)
CLSI	0	0	0	0	0	1	1	2	1	0	3.031	4	8
EUCAST	0	0	0	0	0	0	1	1	3	0	5.278	8	8
T. violaceum (n = 3)
CLSI	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
EUCAST	2	1	0	0	0	0	0	0	0	0	0.037	0.03	0.06
M. gypseum (n = 3)
CLSI	0	2	1	0	0	0	0	0	0	0	0.076	0.06	0.125
EUCAST	0	2	1	0	0	0	0	0	0	0	0.076	0.06	0.125
T. verrucosum (n = 1)
CLSI	0	0	0	0	0	1	0	0	0	0	*NA	*NA	*NA
EUCAST	0	0	0	0	0	0	1	0	0	0	*NA	*NA	*NA
Amphotericin B
T. interdigitale (n = 37)
CLSI	13	4	18	2	0	0	0	0	0	0	0.072	0.125	0.125
EUCAST	13	4	18	2	0	0	0	0	0	0	0.072	0.125	0.125
T. tonsurans (n = 17)
CLSI	4	3	5	0	3	1	1	0	0	0	0.133	0.125	1
EUCAST	0	7	5	0	0	4	1	0	0	0	0.177	0.125	1
T. rubrum (n = 5)
CLSI	1	1	0	2	0	1	0	0	0	0	0.162	0.25	1
EUCAST	0	2	0	1	1	0	1	0	0	0	0.245	0.25	2
T. violaceum (n = 3)
CLSI	0	0	3	0	0	0	0	0	0	0	0.125	0.125	0.125
EUCAST	0	0	2	1	0	0	0	0	0	0	0.157	0.125	0.25
M. gypseum (n = 3)
CLSI	0	0	0	3	0	0	0	0	0	0	0.25	0.25	0.25
EUCAST	0	0	0	3	0	0	0	0	0	0	0.25	0.25	0.25
T. verrucosum (n = 1)
CLSI	0	0	0	0	0	0	1	0	0	0	*NA	*NA	*NA
EUCAST	0	0	0	0	0	0	1	0	0	0	*NA	*NA	*NA

(Note: the underlined values denote the modal MICs; *NA: not applicable; ⁺GM: geometric mean).