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Time-to-kill eradication of Candida tropicalis (CT) biofilm—NiCE lock solution eradicated CT biofilm within 1 h. None of the other lock solutions tested fully eradicated biofilm by the 60 min timepoint. A significant difference (p = 0.002) is denoted with *** between 0.003% NiCE when compared to both TCH and 0.9% saline control. Graph Key: 0.9% saline; 200 U heparin; 30% citrate; 1.35% taurolidine + 3.5% citrate + 1000 U heparin; 0.003% nitroglycerin + 4% citrate + 22% ethanol.
