Figure 3.
Effects of PKC inhibitors and isoenzyme‐specific inhibitor peptides on the action of A61603 and Ang II in isolated guinea pig ventricular cardiomyocytes. (A, C) Representative current traces of IKr recorded under a depolarizing prepulse +40 mV for 2 s and then repolarizing to −40 mV in the presence of Gö6976, Gö6983 or the PKCα and PKCε inhibitor peptides before (black) and after application of 1 μM A61603 (A, grey) or 100 nM Ang II (C, grey). (B) Summary data for the percentage decrease obtained from A. *P < 0.05, significantly different from control. (D) Summary data for the percentage decrease obtained from C. *P < 0.05, significantly different from control). All of cardiomyocytes were taken from five hearts.