Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 4;214(12):3775–3790. doi: 10.1084/jem.20161868

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Veselits et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — Normal T-dependent and T-independent humoral immunity in Igβ^KΔR mice. (A) WT (open red circles) or Igβ^KΔR (open blue squares) mice were immunized with T-independent (NP-Ficoll) or T-dependent (NP-CGG or NP-SRBC) antigens, and sera were assayed for NP-specific IgM antibodies (top) and either low-affinity (middle) or high-affinity (bottom) IgG antibodies by ELISA on the indicated days (each symbol represents assay from one mouse). *, P = 0.002; **, P = 0.001; ***, P = 0.005; †, P = 0.004; ‡, P = 0.05. Horizontal lines represent means. (B and C) WT MD4 or Igβ^KΔRxMD4 were labeled with CFSE and transferred along with HEL-SRBC into B6.SJL-Ptprc^aPepc^b/BoyJ mice. (B) Spleens were harvested 3 d after transfer and analyzed by flow cytometry (n = 5 each group). (C) Spleens were harvested 6 d after transfer/immunization and analyzed by flow cytometry. Individual mice indicated in bar graph (right). Error bars represent mean ± SD.