Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 4;214(12):3645–3667. doi: 10.1084/jem.20170391

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Antila et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — LVs in spinal meninges. (A) Schematic illustration of meningeal LVs (green) attached to the ventral and dorsal sides of the cranium and spinal canal after removal of the brain and spinal cord. SN; spinal nerve. (B) Transverse section of lumbar spine of an adult mouse showing LVs in dura, immunostained for CD31 (green), LYVE1 (red), and PROX1 (blue). (C) Coronal sections of adult skull showing the meningeal LVs, immunostained for CD31 (green), CCL21 (red), and PROX1 (blue). Asterisk indicates an artifactual space created during preparation. (D) LYVE1, VEGFR3, and podoplanin immunostaining of spinal meninges. (E and F) Development of the meningeal LVs in the spinal canal on the ventral (E) and dorsal (F) aspects during the indicated postnatal (P) days. (G) LVs exiting the spinal canal together with the spinal nerves. Arrowheads in E and F point to lymphatic valves, and red asterisks in E indicate BVs. Yellow asterisks in E indicate the connection between LVs around the FM and LVs around the spinal canal. Data shown are representative of n = 3–6 per time point and staining. Bars: (B) 20 µm; (C) 50 µm; (D, F, and G) 400 µm; (E) 300 µm.