Table 1.
Pattern of relapses following treatment for the 27 localized patients and 9 metastatic patients on the SIOP-CNS-GCT-96 trial
| Localized Malignant NGGCT (n = 27) | |||
|---|---|---|---|
| Case | Primary Tumor Site | Tumor Site at Relapse | Relapse Category* |
| 1 | Pineal | Pineal | Locoregional |
| 2 | Pineal | Pineal | Locoregional |
| 3 | Pineal | Pineal | Locoregional |
| 4 | Pineal | Pineal | Locoregional |
| 5 | Pineal | Pineal | Locoregional |
| 6 | Pineal | Pineal + chiasm/suprasellar | Locoregional and distant |
| 7 | Pineal | Pineal + spinal | Locoregional and distant |
| 8 | Pineal | Pineal + suboccipital + spinal | Locoregional and distant |
| 9 | Pineal | Bifocal + spinal | Locoregional and distant |
| 10 | Pineal | Pineal + parietal + spinal | Locoregional and distant |
| 11 | Pineal | Spinal | Distant |
| 12 | Pineal | Leptomeningeal + cranial + spinal | Distant |
| 13 | Pineal | Cranial + spinal | Distant |
| 14 | Pineal | Optic nerve + subependymal frontal horns + globus pallidus | Distant |
| 15 | Pineal | Third ventricle + suprasellar + frontal horns of ventricle + spinal | Distant |
| 16 | Pineal | Floor of third ventricle, chiasm | Distant |
| 17 | Pineal | Cranial | Suspected local relapse, only tumor marker elevation |
| 18 | Suprasellar | Suprasellar | Locoregional |
| 19 | Suprasellar | Suprasellar | Locoregional |
| 20 | Suprasellar | Hypothalamic | Locoregional |
| 21 | Suprasellar | Fourth ventricle | Locoregional |
| 22 | Suprasellar | Subependymal | Distant |
| 23 | Bifocal | Pineal | Locoregional |
| 24 | Frontomedial lobe | Right frontal lobe | Locoregional |
| 25 | Inferior frontal lobe (left) | Left occipital lobe | Locoregional |
| 26 | Internal capsule | Ventricles | Locoregional |
| 27 | Left ventricle | Cranial + ventricle + spinal | Locoregional and distant |
| Metastatic Malignant NGGCT (n = 9) | |||
| Case | Primary Tumor Site and Metastatic Group | Tumor Site at Relapse | Relapse Category* |
| 1 | Pineal micrometastatic |
Spinal | Distant |
| 2 | Pineal macrometastatic |
Extracranial (abdominal) | Distant (outside radiotherapy field) |
| 3 | Pineal macrometastatic |
Cranial | Locoregional |
| 4 | Pineal micrometastatic |
Pineal | Locoregional |
| 5 | Pineal macrometastatic |
Pineal | Locoregional |
| 6 | Suprasellar macrometastatic |
Suprasellar | Locoregional (raised tumor marker) |
| 7 | Bifocal macrometastatic |
Subarachnoid space | Locoregional |
| 8 | Right frontal inferior dura macrometastatic |
Left frontal lobe + spinal | Locoregional and distant |
| 9 | Ventricle micrometastatic |
Spinal | Distant |
Key: micrometastatic = positive CSF cytology only; macrometastatic = radiological metastases present on full neuroaxis imaging (MRI head and spine); localized relapse = locoregional; combined relapse = locoregional and distant. ‘Distant’ here refers to relapses distant from the primary tumor site.