Figure 1.

Structures of the B-domain, TRF2 and D-loop. (A) The B-domain comprises nine positively charged arginine residues (highlighted) that are evolutionarily conserved between mouse and human (39). (B) The B-domain is located at the N-terminus of TRF2. Additionally, TRF2 consists of TRFH dimerization domain, Rap1-binding motif RBM, TIN2-binding motif TBM and C-terminal DNA binding Myb domain that selectively recognizes telomeric DNA. (C) The sequence of the D-loop contains four telomeric repeats in the invading strand. The invading strand was labeled with fluorescein (F). The complementary strand with quencher OQA (Q) was added exclusively for thermal stability measurements.