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ASGR2 is not required for increased potency of GalNAc-conjugated ASOs in vitro or in vivo. (A) Dose-response and IC50 of GalNAc–ASO conjugate in ASGR1 vs ASGR1/ASGR2 receptor expressing HEK 293 cells. (B) Activity of GalNAc-conjugated ASO dosed alone or in combination with ASOs targeting ASGR1 and/or ASGR2 in mouse liver. Doses are expressed as mg ASO/kg body weight.
