Fig. 3.

Group differences in functional connectivity between the left ACC and two distinct clusters at/near the left cuneus. A. For visualization purposes, the top and middle panel show the whole-brain FWE-significant connectivity patterns with the left ACC seed, for the impulsive aggression (cut-off = 5.774) and combat control groups (cut-off = 5.668), respectively. Note: voxels in the immediate proximity of the seed-region (clear blue) were set to zero for purposes of visualization and scaling. Cluster-based analysis revealed significant group-differences in a region spanning the left cuneus, calcarine cortex, and superior occipital cortex (cluster 1: dark red), as well as a second region again spanning the left cuneus, calcarine cortex, and superior occipital cortex (cluster 2: light red) (bottom panel; voxel-level p-value < 0.005, k ≥ 20). B. Mean β-weight values were observed to be (relatively) positive in the impulsive aggression group for both the first (cluster 1: mean β-weight = 0.046 ± 0.008) and second (cluster 2: mean β-weight = 0.027 ± 0.023) of these clusters, whereas negative values were observed in the combat control group (cluster 1: mean β-weight = -0.031 ± 0.007; cluster 2: mean β-weight = -0.060 ± 0.022, respectively).