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Chronic ethanol intake changes the “methylation index” in cerebellum. (A) Amounts of S-adenosyl-methionine (SAM) and S-adenosyl-homocysteine (SAH) were measured (mol/mg tissue x10-12) and (B) expressed as a ratio, indicating the methylation index. Global (C) methylation (5mC) and (D) hydroxymethylation (5hmC) were determined. Values are mean ± SEM of 18 samples per group. *P < .05, Student’s t test vs controls.
