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. 2017 Aug 19;20(12):1013–1026. doi: 10.1093/ijnp/pyx075

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© The Author(s) 2017. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — GABA_A receptor delta subunit expression is reduced in the cerebellum of alcohol use disorders subjects. (A) mRNA levels of GABA_A receptor δ (GABRD), α₆ (GABRA6), α₁ (GABRA1) subunits, and (B) 5-α-reductase 1 (SRD5A1) are expressed as fold change of controls. Methylated DNA immunoprecipitation (MeDIP) of the regulatory promoter regions of (C) GABRD and (D) GABRA6 are measured as percentage of input. Hydroxymethylated DNA immunoprecipitation (hMeDIP) of the regulatory promoter regions of (E) GABRD and (F) GABRA6. (G) Protein levels of GABRD measured as ratio of GABRD/GAPDH O.D. values are expressed as percentage of controls. Representative western blot is shown in the lower right-hand corner. Values are mean ± SEM of 24 samples per group for mRNA assays, 11 to 13 samples per group for the immunoprecipitation analysis; 25 samples per group were used for the western blot. *P < .05, Student’s t test vs controls.