Table 1.
Overview of the most relevant indications for PET imaging in meningioma patients
| Clinical Indication | PET Ligands for Somatostatin Receptors | Amino Acid PET Tracers | Other PET Tracers |
|---|---|---|---|
| Detection of meningioma tissue/ differential diagnosis | 68Ga-DOTATOC and 68Ga-DOTATATE PET may add valuable diagnostic information24 ,53 | na | na |
| Meningioma grading | 68Ga-DOTATATE binding correlates with tumor growth rate in WHO grades I and II meningiomas35 |
11C-MET correlates with proliferative activity,54
but data on grading are controversial.34
,55
Static and dynamic 18F-FET PET may provide additional information for meningioma grading32 |
11C-choline seems to be helpful for meningioma grading.41
11C-acetate seems not to be helpful18 |
| Delineation of tumor extent for resection planning |
68Ga-DOTATATE PET delineates the meningioma extent better than standard MRI23 ,61 | na | na |
| Delineation of tumor extent for radiation treatment planning |
68Ga-DOTATOC PET delivers additional information on tumor extent for radiotherapy target definition56 ,57 ,64 ,65 | 11C-MET PET significantly influences GTV delineation in meningiomas31 ,59 | na |
| Treatment monitoring |
na |
11C-MET PET allows an earlier evaluation of treatment effects than standard imaging.66 ,67 Boronated amino acid PET probes may help to evaluate treatment effects38 |
na |
| Diagnosis of tumor progression/differentiation of tumor progression from posttreatment changes |
68Ga-DOTATOC/68Ga-DOTATATE PET is useful for differentiation between progression and posttreatment changes23 ,24 ,52 | na | na |
na = not available.