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. 2017 Dec 4;216(12):4235–4254. doi: 10.1083/jcb.201701108

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© 2017 Romano et al.

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Figure 6. — Role of TgGRA2 and TgGRA6 on the internalization of host LDL-containing endosomes into the PV. (A) TEM of PVs in HFF (24 h): RH, RH with exogenously added 0.2 mM OA, Δgra2, and Δgra2Δgra6 parasites. Bars, 400 nm. (B and C) Δgra2 infected VERO cells (24 h) incubated with LDL-gold complexes for 20 h. (B) Δgra2 PV with host LDL–containing endosomes (arrowheads) along the edge of the PV in the host cytosol. Bars: 800 nm; (inset) 200 nm. (C) Example of a few Δgra2 PVs with intra-PV host LDL–containing endosomes. Bars: 300 nm; (inset) 200 nm. (D) Δgra2Δgra6-infected VERO cells (24 h) incubated with LDL-gold for 20 h. Arrowheads indicate LDL-containing endosomes outside the PV. Bar, 800 nm. (E) Δgra2Δgra6 infected VERO cells with exogenously added 0.2 mM OA. Bar, 800 nm. (F) The percentage of PVs with different abundances of intra-PV host LDL–containing endosomes.