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. 2017 Dec 4;216(12):4041–4052. doi: 10.1083/jcb.201703096

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© 2017 Ribet et al.

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Figure 4. — Non-SUMOylatable septin variants form aberrant bundles. (a) Fluorescent light microscopy images of HeLa cells transfected with HA-tagged WT or non-SUMOylatable SEPT7 and SEPT11 variants. Cells were stained for HA-tagged septins (anti-HA antibodies, green) and endogenous septins (anti-SEPT2 antibodies, red). (b) Percentage of HeLa cells displaying aberrant septin bundles after transfection with WT or mutant SEPT6, SEPT7, SEPT9, or SEPT11 (mean from three independent experiments; error bars, SD; ***, P < 0.001). (c) Examples of aberrant septin bundles observed in cells expressing non-SUMOylatable SEPT6, SEPT7, and SEPT11 variants. Cells were stained for HA-tagged septins (anti-HA antibodies). Bars, 5 µm.