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. 2017 Dec 4;216(12):4299–4311. doi: 10.1083/jcb.201704044

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© 2017 Druelle et al.

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Figure 6. — Sst-Cre::Pax4OE endogenous and supplementary insulin⁺ cells express a bona fide a β cell–specific transcription factor complement. Representative photographs of immunofluorescence analyses on pancreatic sections of controls (n > 5; A, B, E, F, I, J, M, N, Q, R, U, and V) and Sst-Cre::Pax4-OE (n > 5; C, D, G, H, K, L, O, P, S, T, W, and X). All insulin⁺ cells (preexisting and neo-generated) uniformly expressed the bona fide β cell markers PC1/3 (A–D), Glut-2 (E–H), Nkx6.1 (I–L), and Pdx1 (M–P) and the pan-endocrine markers NeuroD1 (Q–T) and Pax6 (U–X). Bars, 50 µm. INS, insulin.