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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Aug 15;24(19):4708–4713. doi: 10.1016/j.bmcl.2014.08.021

Table 3.

Structure and activity of analogues 17

graphic file with name nihms626371u3.jpg
Compd R % Max PAC-1 bindinga
17a graphic file with name nihms626371t1.jpg 120
17b graphic file with name nihms626371t3.jpg 62
17c graphic file with name nihms626371t4.jpg 71
17d graphic file with name nihms626371t2.jpg 81
17e graphic file with name nihms626371t8.jpg 84
17f graphic file with name nihms626371t9.jpg 95
a

Values indicate the percentage of Max PAC-1 binding after PAR4-AP stimulation of human platelets.16