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. 2017 Dec 4;15:245. doi: 10.1186/s12967-017-1350-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Multiple linear regression models in a subgroup of CFS patients (n = 29). a Previous established associations between blood monocyte count and plasma cortisol, and the expression in whole blood of the genes TNFRSF13C (tumor necrosis factor receptor superfamily member 13C) and CXCR5 (C-X-C motif chemokine receptor 5) (Nguyen et al. [13]). b The associations after introducing TGF-β3 as a mediating variable in the regression model. Significant associations are indicated with a continuous arrow, associations close to the level of significance are indicated with a dotted arrow. B-Mono blood monocyte count, P-Cortisol plasma cortisol, P-TGF plasma transforming growth factor