Table 1.

Criteria of lung cancer histological diagnosis

Histological type	Criteria	Correct classification (%)
NSCLC	SCC≥2 ng/mL and ProGRP<100 pg/mL	97.9
	SCC<2 ng/mL and ProGRP<100 pg/mL and CYFRA 21-1>3.3 ng/mL	92.8
	SCC<2 ng/mL and ProGRP<100 pg/mL and CEA>5 ng/mL	95.3
SCLC	SCC<2 ng/mL and ProGRP≥100 pg/mL and NSE≥35 ng/mL	91.4
	SCC<2 ng/mL and ProGRP>150 pg/mL	90.5
AD	SCC<2 ng/mL and ProGRP<100 pg/mL and CEA>5 ng/mL	85.8
SQC	SCC≥2 ng/mL and ProGRP<100 pg/mL and CA 125<100 U/mL and CYFRA 21-1≥3.3 ng/mL	79.5

Note: Adapted from Liu L, Teng J, Zhang L, et al. The combination of the tumor markers suggests the histological diagnosis of lung cancer. Biomed Res Int. 2017;2017:9.⁵⁶

Abbreviations: NSCLC, non-small-cell lung cancer; SCLC, small-cell lung cancer; AD, adenocarcinoma; SQC, squamous carcinoma.