Figure 1.

Overview of altered circRNA in the Exp A and Ctrl A groups. (A) Heat map of differentially expressed circRNA of CRC samples. Column 1 and 2 in Exp A represent the expression of circRNA in Exp A, while column 1 and 2 in Ctrl A represent the expression of corresponding circRNA in Ctrl A. 4, the lowest normalized intensity of each sample (log₂ transformed); 9, middle normalized intensity of each sample (log₂ transformed); 14, the highest normalized intensity of each sample (log₂ transformed). (B) The circRNA were classified into five types according to the relationship of the genomic loci with their associated coding genes. (C) The top 10 upregulated and downregulated circRNA based on the log fold change. Exp A, CRC tissues from patients with lung metastasis; Ctrl A, CRC tissues from patients without metastasis; circRNA, circular RNA; CRC, colorectal cancer.