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. 2017 Oct 11;40(6):1649–1656. doi: 10.3892/ijmm.2017.3183

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Proposed model for the role of focal adhesion kinase (FAK) in the metastasis of human epidermal growth factor receptor-2 (HER-2)-positive breast cancer cells. HER-2/FAK increases the phosphorylation of FAK/cSrc/p130^Cas signaling. The phosphorylation of FAK reduces the expression of the epithelial maker, E-cadherin, and increases the expression of the mesenchymal markers, vimentin and fibronectin, the leading processes of epithelial-mesenchymal transition (EMT). The aforementioned processes promote cell migration and invasion to facilitate the metastasisof breast cancer.