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. 2017 Oct 9;40(6):1709–1718. doi: 10.3892/ijmm.2017.3177

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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In preliminary experiment, ISL exhibited chondroprotective effects on a mice ACLT model in a concentration-dependent manner. Mice underwent ACLT operation and received intraperitoneal injections with 10% Tween-80 or ISL as described in Materials and methods. The mice were sacrificed and their knee joints were excised 8 weeks after ACLT operation. (A) Sagittal medial tibial condyle sections stained with H&E (upper) and (B) Safranin O and fast green (lower). Representative microscopic images of sham-operation, vehicle, and different concentration groups (10, 20 and 40 mg/kg) are shown. Scale bars, 400 µm, n=6/group. ISL, isoliquiritigenin; ACLT, anterior cruciate ligament transection; H&E, hematoxylin and eosin.