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. 2017 Sep 29;40(6):1631–1638. doi: 10.3892/ijmm.2017.3167

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Proliferating cell nuclear antigen (PCNA), Oct4, p53 and hypoxia-inducible factor-1α (HIF-1α) SUMOylation enhances bone marrow-derived mesenchymal stem cell (BMSC) proliferation, stemness maintenance and resistance to apoptosis. (A) Detection of PCNA and Oct4 expression levels by western blot analysis. (B) Detection of p53 and HIF-1α expression levels by western blotting. (C and D) Quantification of data in A. ^*p<0.05, compared with PBS group. (E and F) Quantification of data in B. ^*p<0.05, compared with the control group. (G) A putative regulatory model of hypothermic induction of protein SUMOylation that enhances proliferation, stemness maintenance, and resistance to apoptosis in BMSCs.