Table 6.
Sertoli-Leydig cell tumor and Gynandroblastoma: Prognostic factors
| DICER1 | Stage | Differentiation | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Predisposing mutation | Tumor- specific mutation | Ia/T1aN0M0 | >Ia /T1a- N0-M0 | Poorly | Well & Intermediate | |
|
| ||||||
| Overall Survival | ||||||
| % | 96.4% | 81.8% | 100% | 82.4% | 85.7% | 97.1% |
|
|
||||||
| p-value | 0.020* | 0.038* | 0.262 | |||
|
| ||||||
|
Recurrence Free Survival % |
92.9% | 72.7% | 100% | 70.6% | 71.4% | 97.1% |
|
|
||||||
| p-value | 0.050* | 0.007* | 0.039* | |||
|
| ||||||
| DICER1 (predisposing vs. tumor-specific) | ---------------- | 55% | 76% | 75% | 55% | |
|
|
||||||
| p- value | 0.252 | 0.263 | ||||
|
| ||||||
|
Age
Median, years (Range) |
16 (4–61) | 21 (2–61) | 16 (2–40) | 16 (4–61) | 19 (4–61) | 16 (2–40) |
|
|
||||||
| p-value | 0.151 | 0.860 | 0.490 | |||