Table 3. Performance of main prognostic scores in predicting 3-month mortality in not-transplanted (NOLT) and transplanted (LT) patients (RFH cohort).
NOLT | AUC | p | cut-off | HR | Sensitivity | Specificity | PPV | NPV |
MELD | 0.671 | 0.007 | 33.4 | 2.595 | 74.2 | 54.2 | 51.1 | 76.5 |
UKELD | 0.674 | 0.006 | 71 | 2.127 | 54.8 | 72.9 | 56.5 | 71.4 |
APACHE 2 | 0.757 | <0.001 | 18 | 13.572 | 96.8 | 45.8 | 53.5 | 95.6 |
APACHE 3 | 0.740 | <0.001 | 101 | 35.870 | 100 | 41.6 | 52.4 | 100 |
SOFA | 0.799 | <0.001 | 11 | 5.2 | 77.4 | 70.8 | 63.1 | 82.9 |
KCH | 0.638 | 0.005 | y | 3.28 | 83.9 | 43.7 | 49 | 80.8 |
CLIF-C OF | 0.793 | <0.001 | 12 | 38.914 | 93.5 | 58.3 | 59.1 | 93.2 |
CLIF-C ACLF | 0.762 | <0.001 | 46 | 9.059 | 93.5 | 52.1 | 55.7 | 92.5 |
LT | AUC | p | cut-off | HR | Sensitivity | Specificity | PPV | NPV |
MELD | 0.564 | NS | 40.7 | 2.952 | 33.3 | 100 | 100 | 76.4 |
UKELD | 0.724 | NS | 74 | 0.298 | 100 | 38.5 | 42.8 | 100 |
APACHE 2 | 0.558 | NS | 32 | 3.093 | 50 | 84.6 | 59.9 | 78.5 |
APACHE 3 | 0.557 | NS | 140 | 2.305 | 66.6 | 69.2 | 49.9 | 81.7 |
SOFA | 0.532 | NS | 9 | 0.69 | 33.3 | 92.3 | 66.6 | 74.9 |
KCH | 0.628 | NS | n | 0.409 | 33.3 | 92.3 | 66.6 | 74.9 |
CLIF-C OF | 0.577 | NS | 16 | 0.513 | 100 | 15.4 | 35.3 | 100 |
CLIF-C ACLF | 0.660 | NS | 60 | 0.386 | 100 | 38.5 | 42.8 | 100 |
AUC: area under the curve; HR, hazard ratio; PPV, positive predictive value; NPV, negative predictive value; MELD, model for end-stage liver disease; UKELD, United Kingdom model for end-stage liver disease; APACHE, acute physiology in chronic health evaluation; SOFA, Sequential organ failure assessment; CLIF-C OF, Chronic liver failure-consortium organ failures; CLIF-C ACLF, Chronic liver failure-consortium acute on chronic liver failure.