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. 2017 Dec 5;12(12):e0188715. doi: 10.1371/journal.pone.0188715

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© 2017 Parker et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Animal numbers: lynx1WT/α6WT = 6, lynx1KO/α6WT = 4, lynx1WT/α6L9′S = 7, lynx1KO/α6L9′S = 4. A) Total nicotine-induced DA release from striatal (ST) synaptosomes. Lynx1WT/α6WT and lynx1KO/α6WT differ significantly at 0.01 μM nicotine (p = 0.031), designated by ^. Lynx1WT/α6L9′S and lynx1KO/α6L9′S differ significantly at 1 μM (p = 0.023) and 10 μM (p = 0.024) nicotine, designated by *. B) α-CtxMII-sensitive nicotine-mediated DA release from ST synaptosomes. Lynx1WT/α6WT and lynx1KO/α6WT differ significantly at 1 μM nicotine (p = 0.015). Lynx1WT/α6L9′S and lynx1KO/α6L9′S differ significantly at 1 μM (p = 0.022) and 10 μM (p = 0.042) nicotine. C) α-CtxMII-resistant nicotine-mediated DA release from ST synaptosomes. There were no significant differences between lynx1WT/α6WT and lynx1KO/α6WT or between lynx1WT/α6L9′S and lynx1KO/α6L9′S. D) Total nicotine-mediated DA release from olfactory tubercle (OT) synaptosomes. Lynx1WT/α6WT and lynx1KO/α6WT are not significantly different from each other. lynx1WT/α6L9′S and lynx1KO/α6L9′S differ significantly at 1 μM nicotine (p = 0.042). E) α-CtxMII-sensitive nicotine-mediated DA release from OT synaptosomes. Lynx1WT/α6WT and lynx1KO/α6WT do not differ significantly. Lynx1WT/α6L9′S and lynx1KO/α6L9′S differ significantly at 1 μM nicotine (p = 0.010). F) α-CtxMII-resistant nicotine-mediated DA release from OT synaptosomes. There were no significant differences between lynx1WT/α6WT and lynx1KO/α6WT or between lynx1WT/α6L9′S and lynx1KO/α6L9′S.