Table 5. 86Rb+ efflux from crude synaptosomal preparations of HP, vCX, and fCX, for each genotype.
| [nicotine], μM | 0.5 μM | 50 μM | 0.5 μM | 50 μM |
|---|---|---|---|---|
| hippocampus (HP) | lynx1WT/α6WT | lynx1WT/α6WT | lynx1WT/α6L9′S | lynx1WT/α6L9′S |
| 1.34 ± 0.17 (7) | 5.05 ± 0.24 (7) | 1.72 ± 0.27 (6) | 5.19 ± 0.49 (6) | |
| lynx1KO/α6WT | lynx1KO/α6WT | lynx1KO/α6L9′S | lynx1KO/α6L9′S | |
| 1.39 ± 0.14 (5) | 5.62 ± 0.73 (5) | 0.95 ± 0.13 (5) | 5.34 ± 0.53 (5) | |
| visual cortex (vCX) | lynx1WT/α6WT | lynx1WT/α6WT | lynx1WT/α6L9′S | lynx1WT/α6L9′S |
| 1.65 ± 0.12 (7) | 8.25 ± 0.46 (7) | 1.58 ± 0.23 (6) | 7.49 ± 0.72 (6) | |
| lynx1KO/α6WT | lynx1KO/α6WT | lynx1KO/α6L9′S | lynx1KO/α6L9′S | |
| 1.46 ± 0.22 (5) | 6.70 ± 0.62 (5) | 1.56 ± 0.23 (5) | 6.93 ± 0.72 (5) | |
| frontal cortex (fCX) | lynx1WT/α6WT | lynx1WT/α6WT | lynx1WT/α6L9′S | lynx1WT/α6L9′S |
| 1.75 ± 0.25 (7) | 6.84 ± 0.36 (7) | 1.79 ± 0.12 (6) | 7.38 ± 0.73 (6) | |
| lynx1WT/α6WT | lynx1WT/α6WT | lynx1WT/α6L9′S | lynx1WT/α6L9′S | |
| 1.57 ± 0.30 (5) | 6.77 ± 0.56 (5) | 2.13 ± 0.35 (5) | 6.65 ± 0.89 (5) |
Data are normalized to baseline and given as mean ± sem (n). No significant differences among lynx1 or α6 genotypes were noted.